Ezrin-anchored PKA Coordinates Phosphorylation-dependent Disassembly of a NHERF1 Ternary Complex to Regulate Hormone-sensitive Phosphate Transport
نویسندگان
چکیده
Ezrin-anchored PKA Coordinates Phosphorylation-dependent Disassembly of a NHERF1 Ternary Complex to Regulate Hormone-sensitive Phosphate Transport Bin Wang, Chris K. Means, Yanmei Yang, Tatyana Mamonova, Alessandro Bisello, Daniel L. Altschuler, John D. Scott, and Peter A. Friedman From the Laboratory for G Protein-Coupled Receptor Biology, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, and Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195 Running head: Npt2a-NHERF1-ezrin ternary complex regulates Pi transport Correspondence and requests for materials should be addressed to Peter A. Friedman, PhD, University of Pittsburgh School of Medicine, Department of Pharmacology & Chemical Biology, W1340 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA, 15261. e-mail: [email protected]
منابع مشابه
Ezrin-anchored protein kinase A coordinates phosphorylation-dependent disassembly of a NHERF1 ternary complex to regulate hormone-sensitive phosphate transport.
Congenital defects in the Na/H exchanger regulatory factor-1 (NHERF1) are linked to disordered phosphate homeostasis and skeletal abnormalities in humans. In the kidney, these mutations interrupt parathyroid hormone (PTH)-responsive sequestration of the renal phosphate transporter, Npt2a, with ensuing urinary phosphate wasting. We now report that NHERF1, a modular PDZ domain scaffolding protein...
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